Carboxyl-functionalized graphene oxide-modified electrode for the electrochemical determination of nonsteroidal anti-inflammatory drug diclofenac

Chelladurai Karuppiah, Srikanth Cheemalapati, Shen Ming Chen, Selvakumar Palanisamy

    Research output: Contribution to journalArticlepeer-review

    64 Scopus citations

    Abstract

    A simple and sensitive electrochemical method was proposed for the quantitative determination of nonsteroidal anti-inflammatory drug diclofenac (DCF). For the first time, carboxyl-functionalized graphene oxide (GO-COOH)-modified glassy carbon electrode (GCE) was employed for the determination of DCF by cyclic voltammetry (CV) and linear sweep voltammetric (LSV) techniques. The proposed modified electrode showed strong electrocatalytic activity toward DCF with higher anodic peak enhancement than that of the unmodified electrode. The practicality of the proposed electrode for the detection of DCF in human urine and blood serum samples was successfully demonstrated using LSV techniques. The obtained results were satisfactory. The detection limit and sensitivity of the proposed method were of 0.09 μM and 0.532 μA μM−1 cm−2, respectively (by LSV). Applicability of the proposed method was verified with commercially available pharmaceutical tablets, and the obtained results were in good agreement with the claimed label amounts of the tablets. In addition, this method could be used for the accurate detection of DCF in clinical and pharmaceutical industries in the future.

    Original languageBritish English
    Pages (from-to)231-238
    Number of pages8
    JournalIonics
    Volume21
    Issue number1
    DOIs
    StatePublished - Jan 2014

    Keywords

    • Diclofenac
    • Graphene oxide
    • Oxidation
    • Serum
    • Urine

    Fingerprint

    Dive into the research topics of 'Carboxyl-functionalized graphene oxide-modified electrode for the electrochemical determination of nonsteroidal anti-inflammatory drug diclofenac'. Together they form a unique fingerprint.

    Cite this