Boston type i keratoprosthesis for treatment of gelatinous drop-like corneal dystrophy after repeated graft failure

A. Fadlallah, F. A. Jakobiec, P. R. Mendoza, P. A. Zalloua, S. A. Melki

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Purpose: To describe the use of a Boston type I keratoprosthesis as a secondary penetrating procedure to treat gelatinous drop-like corneal dystrophy (GDLD), with presentation of pathologic findings, genetic analysis, and discussion of other surgical options. Methods: A 43-year-old woman with GDLD in both eyes, best corrected visual acuity (BCVA) of counting fingers in both eyes, and recurrent corneal opacification following two penetrating keratoplasties presented for visual rehabilitation. A Boston type I keratoprosthesis was implanted in her left eye after extracapsular clear lens extraction. Results: The surgery was uneventful and one month after surgery, best corrected vision improved to 20/30, which has been maintained for a period of more than nine months. At the 12-month visit, her vision was noted to be diminished to 20/200 due to a retroprosthetic membrane and improved to 20/25 two weeks after a Yag capsulotomy. Histopathologic examination of the corneal specimen disclosed predominantly subepithelial amyloid deposition. Genetic analysis is presented. Conclusions: GDLD is a rare disorder of primary corneal amyloidosis. Recurrence of this condition following surgery is very common. Boston type I keratoprosthesis as a secondary procedure can be successful in restoring vision in affected patients.

Original languageBritish English
Pages (from-to)150-153
Number of pages4
JournalSeminars in Ophthalmology
Volume30
Issue number2
DOIs
StatePublished - 1 Mar 2015

Keywords

  • Boston type I keratoprosthesis
  • Gelatinous drop-like corneal dystrophy
  • Genetic analysis

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