Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Jonas G. Croissant; Yevhen Fatieiev; Khachatur Julfakyan; Jie Lu; Abdul Hamid Emwas; Dalaver H. Anjum; Haneen Omar; Fuyuhiko Tamanoi; Jeffrey I. Zink; Niveen M. Khashab

doi:10.1002/chem.201601714

Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Jonas G. Croissant
, Yevhen Fatieiev
, Khachatur Julfakyan
, Jie Lu
, Abdul Hamid Emwas
, Dalaver H. Anjum
, Haneen Omar
, Fuyuhiko Tamanoi
, Jeffrey I. Zink
, Niveen M. Khashab

Physics

King Abdullah University of Science and Technology
University of California Los Angeles

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

Original language	British English
Pages (from-to)	14806-14811
Number of pages	6
Journal	Chemistry - A European Journal
Volume	22
Issue number	42
DOIs	https://doi.org/10.1002/chem.201601714
State	Published - 10 Oct 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biodegradable
bridged silsesquioxanes
drug delivery
enzymes
nanoparticles

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10.1002/chem.201601714

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title = "Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells",

abstract = "We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt \%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.",

keywords = "biodegradable, bridged silsesquioxanes, drug delivery, enzymes, nanoparticles",

author = "Croissant, \{Jonas G.\} and Yevhen Fatieiev and Khachatur Julfakyan and Jie Lu and Emwas, \{Abdul Hamid\} and Anjum, \{Dalaver H.\} and Haneen Omar and Fuyuhiko Tamanoi and Zink, \{Jeffrey I.\} and Khashab, \{Niveen M.\}",

note = "Funding Information: The authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work. Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2016",

month = oct,

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doi = "10.1002/chem.201601714",

language = "British English",

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journal = "Chemistry - A European Journal",

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T1 - Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

AU - Croissant, Jonas G.

AU - Fatieiev, Yevhen

AU - Julfakyan, Khachatur

AU - Lu, Jie

AU - Emwas, Abdul Hamid

AU - Anjum, Dalaver H.

AU - Omar, Haneen

AU - Tamanoi, Fuyuhiko

AU - Zink, Jeffrey I.

AU - Khashab, Niveen M.

N1 - Funding Information: The authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work. Publisher Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2016/10/10

Y1 - 2016/10/10

N2 - We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

AB - We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

KW - biodegradable

KW - bridged silsesquioxanes

KW - drug delivery

KW - enzymes

KW - nanoparticles

UR - https://www.scopus.com/pages/publications/84977550437

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DO - 10.1002/chem.201601714

M3 - Article

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AN - SCOPUS:84977550437

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VL - 22

SP - 14806

EP - 14811

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 42

ER -

Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Abstract

UN SDGs

Keywords

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