Bioaffinity limitations for anisotropically etched silicon microfluidics

Anas Alazzam, Arvind Chandrasekaran, Muthukumaran Packirisamy, Ion Stiharu, Rama Bhat

Research output: Contribution to journalArticlepeer-review

Abstract

Immobilisation of biological specimens is an essential process in biomicrofluidics for micro total analysis systems (μTASs) applications, to carry out high throughput bioassays. Closed microfluidic channels restrict immobilisation feasibilities to only direct conjugation of the biomolecules with the channel surface through appropriate flow control-based incubation techniques. In this work, the limitations of bioaffinity on anisotropically etched silicon microfluidic channels have been studied. The flow behaviour within the microchannels has been analysed by solving the Navier-Stokes equation using finite element method (FEM). The results have been used to predict the immobilisation and rinsing behaviour within anisotropically etched trapezoidal and triangular microfluidic channels.

Original languageBritish English
Pages (from-to)122-132
Number of pages11
JournalInternational Journal of Abrasive Technology
Volume3
Issue number2
DOIs
StatePublished - Jun 2010

Keywords

  • Anisotropic etching
  • Bioaffinity
  • Biosensing
  • FEA
  • Finite element analysis
  • Immobilisation
  • Lab-on-a-chip
  • Micro total analysis systems
  • Microfluidics
  • Silicon
  • Stagnant flow
  • μtass

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