Bio-mitigation of organic pollutants using horseradish peroxidase as a promising biocatalytic platform for environmental sustainability: Environmental Research

M. Bilal, A.K. Singh, H.M.N. Iqbal, T.H. Kim, G. Boczkaj, K. Athmaneh, S.S. Ashraf

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A wide array of environmental pollutants is often generated and released into the ecosystem from industrial and human activities. Antibiotics, phenolic compounds, hydroquinone, industrial dyes, and Endocrine-Disrupting Chemicals (EDCs) are prevalent pollutants in water matrices. To promote environmental sustainability and minimize the impact of these pollutants, it is essential to eliminate such contaminants. Although there are multiple methods for pollutants removal, many of them are inefficient and environmentally unfriendly. Horseradish peroxidase (HRP) has been widely explored for its ability to oxidize the aforementioned pollutants, both alone and in combination with other peroxidases, and in an immobilized way. Numerous positive attributes make HRP an excellent biocatalyst in the biodegradation of diverse environmentally hazardous pollutants. In the present review, we underlined the major advancements in the HRP for environmental research. Numerous immobilization and combinational studies have been reviewed and summarized to comprehend the degradability, fate, and biotransformation of pollutants. In addition, a possible deployment of emerging computational methodologies for improved catalysis has been highlighted, along with future outlook and concluding remarks. © 2023 Elsevier Inc.
Original languageBritish English
JournalEnviron. Res.
StatePublished - 2023


  • Emerging pollutants
  • Environmental consequences
  • Enzyme immobilization
  • Pharmaceuticals degradation
  • Wastewater treatment
  • Anti-Bacterial Agents
  • Catalysis
  • Ecosystem
  • Environmental Pollutants
  • Horseradish Peroxidase
  • Humans
  • Peroxidases
  • Biodegradation
  • Endocrine disrupters
  • Food products
  • Industrial chemicals
  • Organic pollutants
  • Phenols
  • Sustainable development
  • Water pollution
  • 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid)
  • antibiotic agent
  • caffeic acid
  • cimetidine
  • endocrine disruptor
  • furosemide
  • horseradish peroxidase
  • hydrochlorothiazide
  • hydrogen peroxide
  • hydroquinone
  • indole
  • lincomycin
  • meloxicam
  • mercaptobenzothiazole
  • norfloxacin
  • peroxidase
  • phenol derivative
  • roxithromycin
  • sulfadimidine
  • sulfamethoxazole
  • tiabendazole
  • venlafaxine
  • antiinfective agent
  • Endocrine disrupting chemicals
  • Environmental pollutants
  • Environmental sustainability
  • Horse-radish peroxidase
  • Human activities
  • Industrial activities
  • Pharmaceutical degradation
  • Phenolic compounds
  • biodegradation
  • biotransformation
  • catalysis
  • drug
  • enzyme activity
  • immobilization
  • mitigation
  • organic pollutant
  • pollutant removal
  • sustainability
  • wastewater treatment
  • Article
  • biocatalyst
  • bioremediation
  • computer model
  • degradation
  • ecosystem restoration
  • environmental impact
  • environmental mitigation
  • environmental sustainability
  • enzyme structure
  • Fenton reaction
  • pollutant
  • ecosystem
  • human


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