Bifunctional thiourea-catalyzed asymmetric addition of anthrones to maleimides

Alex Zea, Guillem Valero, Andrea Nekane R. Alba, Albert Moyano, Ramon Rios

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

For the first time, the addition of anthrones to maleimides catalyzed by bifunctional thiourea catalysts is reported. The thiourea moiety is able to activate the maleimide and the tertiary amine deprotonates the anthrone, furnishing the final DielsAlder or Michael adducts in excellent yields and enantioselectivities.

Original languageBritish English
Pages (from-to)1102-1106
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume352
Issue number7
DOIs
StatePublished - 3 May 2010

Keywords

  • Anthrones
  • Diels-alder cycloaddition
  • Enantioselective
  • Maleimides
  • Michael addition
  • Organocatalysis

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