@article{51e966b0cc94408eb01c82c42d681f92,
title = "Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents",
abstract = "An unprecedented reaction of thiourea derivatives with 6β-bromoandrostenedione has been discovered for the formation of aminothiazolo-androstenones via a simple, safer, cascade protocol that enables the syntheses of novel molecules by using readily available reagents. The reaction mechanism of product formation has been rationalized by density functional theory calculations. This benign methodology accentuates a domino protocol deploying a renewable solvent, ethanol, while generating novel compounds that display potent growth inhibitory effects in in vitro studies for several cancer cell lines at submicromolar concentrations.",
author = "Ali, {Mohamad Akbar} and Christina Okolo and Alsharif, {Zakeyah A.} and Jedidiah Whitt and Chambers, {Steven A.} and Varma, {Rajender S.} and Alam, {Mohammad A.}",
note = "Funding Information: We are thankful to the INBRE for a pilot grant (Grant No. 224658). This publication was made possible by the Research Technology Core of the Arkansas INBRE Program, supported by a grant from the National Institute of General Medical Sciences, (NIGMS), P20 GM103429-16, from the National Institutes of Health to record the mass spectrometry data. We are thankful to Dr. Victor, Director/Senior Scientist X-ray Crystallography Laboratory University of Kansas (NSF-MRI grant CHE-0923449), for recording the crystal structures of compounds. Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = sep,
day = "21",
doi = "10.1021/acs.orglett.8b02587",
language = "British English",
volume = "20",
pages = "5927--5932",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "18",
}
