@article{c6cfe659f5864082a7d9d884e908289f,
title = "Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery",
abstract = "In an effort to synthesize a library of bioactive molecules, we present an efficient synthesis of fused-thiazole derivatives of natural products and approved drugs by using an environmentally usable solvent, acetic acid, and without any external reagent. Cholestenone, ethisterone, progesterone, and nootkatone-derived epoxyketones have been utilized to synthesize 50 novel compounds. The plausible mechanism of the reaction has been determined by theoretical calculation using M06-2X/6-31+G(d,p). These novel molecules have been tested against cancer cell lines and pathogenic bacterial strains. Several ethisterone-based fused-thiazole compounds are found to be potent growth inhibitors of cancer cell lines at submicromolar concentrations.",
author = "Rawan Alnufaie and Ali, {Mohamad Akbar} and Alkhaibari, {Ibrahim S.} and Subrata Roy and Day, {Victor W.} and Alam, {Mohammad A.}",
note = "Funding Information: This manuscript was made possible by the support from the Winthrop P. Rockefeller Cancer Institute at the University of Arkansas for Medical Sciences (UAMS), Little Rock, USA. This publication was made possible by the Arkansas INBRE program and the Research Technology Core of the Arkansas INBRE program, and supported by a grant from the National Institute of General Medical Sciences, (NIGMS), P20 GM103429 from the National Institutes of Health. NSF-MRI grant CHE-0923449 that was used to purchase the X-ray diffractometer and software used in this study is acknowledged. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2021.",
year = "2021",
month = apr,
day = "7",
doi = "10.1039/d1nj00380a",
language = "British English",
volume = "45",
pages = "6001--6017",
journal = "New Journal of Chemistry",
issn = "1144-0546",
publisher = "Royal Society of Chemistry",
number = "13",
}
