Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa, Ellen Kanitz, Winfried Otten, Saleh M. Ibrahim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

31 Scopus citations


We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

Original languageBritish English
Title of host publicationNeuroimmunomodulation
Subtitle of host publicationFrom Fundamental Biology to Therapy
Number of pages8
StatePublished - Feb 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • ATP8
  • Conplastic mouse strain
  • Corticosterone
  • Depression
  • Dopamine
  • Elevated plus maze
  • HPA reactivity
  • Mitochondrial substitution
  • mtDNA
  • Noradrenaline
  • Psychosocial stress
  • Serotonin


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