Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa, Ellen Kanitz, Winfried Otten, Saleh M. Ibrahim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

31 Scopus citations

Abstract

We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

Original languageBritish English
Title of host publicationNeuroimmunomodulation
Subtitle of host publicationFrom Fundamental Biology to Therapy
Pages131-138
Number of pages8
DOIs
StatePublished - Feb 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1153
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • ATP8
  • Conplastic mouse strain
  • Corticosterone
  • Depression
  • Dopamine
  • Elevated plus maze
  • HPA reactivity
  • Mitochondrial substitution
  • mtDNA
  • Noradrenaline
  • Psychosocial stress
  • Serotonin

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