Automating the processing of cDNA microarray images

P. Liatsis; M. A. Nazarboland; J. Y. Goulermas; X. J. Zeng; E. Milonidis

doi:10.1504/IJISTA.2008.01817

Automating the processing of cDNA microarray images

P. Liatsis, M. A. Nazarboland, J. Y. Goulermas, X. J. Zeng, E. Milonidis

Electrical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

This work is concerned with the development of an automatic image processing tool for DNA microarray images. This paper proposes, implements and tests a new tool for cDNA image analysis. The DNAs are imaged as thousands of circularly shaped objects (spots) on the microarray image and the purpose of this tool is to correctly address their location, segment the pixels belonging to spots and extract the quality features of each spot. Techniques used for addressing, segmentation and feature extraction of spots are described in detail. The results obtained with the proposed tool are systematically compared with conventional cDNA microarray analysis software tools.

Original language	British English
Pages (from-to)	115-144
Number of pages	30
Journal	International Journal of Intelligent Systems Technologies and Applications
Volume	5
Issue number	1-2
DOIs	https://doi.org/10.1504/IJISTA.2008.01817
State	Published - 2008

Keywords

addressing
cDNA microarrays
feature extraction
gene expression levels
segmentation
spot detection

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10.1504/IJISTA.2008.01817

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abstract = "This work is concerned with the development of an automatic image processing tool for DNA microarray images. This paper proposes, implements and tests a new tool for cDNA image analysis. The DNAs are imaged as thousands of circularly shaped objects (spots) on the microarray image and the purpose of this tool is to correctly address their location, segment the pixels belonging to spots and extract the quality features of each spot. Techniques used for addressing, segmentation and feature extraction of spots are described in detail. The results obtained with the proposed tool are systematically compared with conventional cDNA microarray analysis software tools.",

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AU - Milonidis, E.

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AB - This work is concerned with the development of an automatic image processing tool for DNA microarray images. This paper proposes, implements and tests a new tool for cDNA image analysis. The DNAs are imaged as thousands of circularly shaped objects (spots) on the microarray image and the purpose of this tool is to correctly address their location, segment the pixels belonging to spots and extract the quality features of each spot. Techniques used for addressing, segmentation and feature extraction of spots are described in detail. The results obtained with the proposed tool are systematically compared with conventional cDNA microarray analysis software tools.

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KW - cDNA microarrays

KW - feature extraction

KW - gene expression levels

KW - segmentation

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Automating the processing of cDNA microarray images

Abstract

Keywords

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