Asymmetric amplification in the amino acid-catalyzed synthesis of amino acid derivatives

Ismail Ibrahem; Henrik Sundén; Pawel Dziedzic; Ramon Rios; Armando Córdova

doi:10.1002/adsc.200700110

Asymmetric amplification in the amino acid-catalyzed synthesis of amino acid derivatives

Ismail Ibrahem, Henrik Sundén, Pawel Dziedzic, Ramon Rios, Armando Córdova

Chemistry

Arrhenius Laboratory

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The origins of biological homochirality have intrigued researchers since Pasteur's discovery of the optical activity of biomolecules. Herein, we present the first example of asymmetric amplification in the amino acid-catalyzed enantioselective synthesis of amino acid derivatives that provides support for a synergistic model for the evolution of homochirality by amino acid catalysis.

Original language	British English
Pages (from-to)	1868-1872
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	349
Issue number	11-12
DOIs	https://doi.org/10.1002/adsc.200700110
State	Published - Aug 2007

Keywords

Amino acids
Asymmetric amplification
Homochirality
Kinetic resolution

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10.1002/adsc.200700110

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abstract = "The origins of biological homochirality have intrigued researchers since Pasteur's discovery of the optical activity of biomolecules. Herein, we present the first example of asymmetric amplification in the amino acid-catalyzed enantioselective synthesis of amino acid derivatives that provides support for a synergistic model for the evolution of homochirality by amino acid catalysis.",

keywords = "Amino acids, Asymmetric amplification, Homochirality, Kinetic resolution",

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AU - Ibrahem, Ismail

AU - Sundén, Henrik

AU - Dziedzic, Pawel

AU - Rios, Ramon

AU - Córdova, Armando

PY - 2007/8

Y1 - 2007/8

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AB - The origins of biological homochirality have intrigued researchers since Pasteur's discovery of the optical activity of biomolecules. Herein, we present the first example of asymmetric amplification in the amino acid-catalyzed enantioselective synthesis of amino acid derivatives that provides support for a synergistic model for the evolution of homochirality by amino acid catalysis.

KW - Amino acids

KW - Asymmetric amplification

KW - Homochirality

KW - Kinetic resolution

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DO - 10.1002/adsc.200700110

M3 - Article

AN - SCOPUS:34548394458

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VL - 349

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EP - 1872

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 11-12

ER -

Asymmetric amplification in the amino acid-catalyzed synthesis of amino acid derivatives

Abstract

Keywords

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