Association of hypertension with coronary                      artery disease onset in the Lebanese population

Aline Milane; Jad Abdallah; Roy Kanbar; Georges Khazen; Michella Ghassibe-Sabbagh; Angelique K. Salloum; Sonia Youhanna; Aline Saad; Hamid El Bayeh; Elie Chammas; Daniel E. Platt; Jörg Hager; Dominique Gauguier; Pierre Zalloua; Antoine Abchee

doi:10.1186/2193-1801-3-533

Association of hypertension with coronary artery disease onset in the Lebanese population

Aline Milane
, Jad Abdallah
, Roy Kanbar
, Georges Khazen
, Michella Ghassibe-Sabbagh
, Angelique K. Salloum
, Sonia Youhanna
, Aline Saad
, Hamid El Bayeh
, Elie Chammas
, Daniel E. Platt
, Jörg Hager
, Dominique Gauguier
, Pierre Zalloua
, Antoine Abchee

College of Medicine and Health Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001).

In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.

This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated.

The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population.

Original language	British English
Article number	533
Pages (from-to)	1-7
Number of pages	7
Journal	SpringerPlus
Volume	3
Issue number	1
DOIs	https://doi.org/10.1186/2193-1801-3-533
State	Published - 24 Sep 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antihypertensive drugs
Coronary artery disease (CAD)
Hypertension
Lebanese population
Risk factors
Therapeutic lifestyle changes

Access to Document

10.1186/2193-1801-3-533

Cite this

Milane, A., Abdallah, J., Kanbar, R., Khazen, G., Ghassibe-Sabbagh, M., Salloum, A. K., Youhanna, S., Saad, A., El Bayeh, H., Chammas, E., Platt, D. E., Hager, J., Gauguier, D., Zalloua, P., & Abchee, A. (2014). Association of hypertension with coronary artery disease onset in the Lebanese population. SpringerPlus, 3(1), 1-7. Article 533. https://doi.org/10.1186/2193-1801-3-533

@article{dbc6192a6d5b4a4093f6688b8dc3217f,

title = "Association of hypertension with coronary artery disease onset in the Lebanese population",

abstract = "Results showed that hypertension is associated with late onset CAD (OR=0.656, 95\% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001).In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated.The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population.",

keywords = "Antihypertensive drugs, Coronary artery disease (CAD), Hypertension, Lebanese population, Risk factors, Therapeutic lifestyle changes",

author = "Aline Milane and Jad Abdallah and Roy Kanbar and Georges Khazen and Michella Ghassibe-Sabbagh and Salloum, \{Angelique K.\} and Sonia Youhanna and Aline Saad and \{El Bayeh\}, Hamid and Elie Chammas and Platt, \{Daniel E.\} and J{\"o}rg Hager and Dominique Gauguier and Pierre Zalloua and Antoine Abchee",

note = "Funding Information: This work was supported by the European Commission [FGENTCARD, grant number LSHG-CT-2006-037683]. We thank the patients for agreeing to participate in the study. We thank Nour Moukalled for her help with subject recruitment and data collection. We thank the Rafic Hariri University Hospital and “Centre Hospitalier du Nord” for their collaboration and support. The FGENTCARD Consortium: Dominique Gauguier, The Wellcome Trust Centre for Human Genetics, University of Oxford, UK; Mark Lathrop, J{\"o}rg Hager, CEA-Genomics Institute, Centre National de G{\'e}notypage, Evry, France; Jeremy K. Nicholson, Imperial College London, UK; Pierre Zalloua, Lebanese American University, School of Medicine, Beirut, Lebanon; Ulla Grove Sidelmann, Novo Nordisk, M{\aa}l{\o}v, Denmark; Frank Bonner, Metabometrix Ltd, London, UK. Publisher Copyright: {\textcopyright} 2014, Milane et al.; licensee Springer.",

year = "2014",

month = sep,

day = "24",

doi = "10.1186/2193-1801-3-533",

language = "British English",

volume = "3",

pages = "1--7",

journal = "SpringerPlus",

issn = "2193-1801",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

Milane, A, Abdallah, J, Kanbar, R, Khazen, G, Ghassibe-Sabbagh, M, Salloum, AK, Youhanna, S, Saad, A, El Bayeh, H, Chammas, E, Platt, DE, Hager, J, Gauguier, D, Zalloua, P & Abchee, A 2014, 'Association of hypertension with coronary artery disease onset in the Lebanese population', SpringerPlus, vol. 3, no. 1, 533, pp. 1-7. https://doi.org/10.1186/2193-1801-3-533

TY - JOUR

T1 - Association of hypertension with coronary artery disease onset in the Lebanese population

AU - Milane, Aline

AU - Abdallah, Jad

AU - Kanbar, Roy

AU - Khazen, Georges

AU - Ghassibe-Sabbagh, Michella

AU - Salloum, Angelique K.

AU - Youhanna, Sonia

AU - Saad, Aline

AU - El Bayeh, Hamid

AU - Chammas, Elie

AU - Platt, Daniel E.

AU - Hager, Jörg

AU - Gauguier, Dominique

AU - Zalloua, Pierre

AU - Abchee, Antoine

N1 - Funding Information: This work was supported by the European Commission [FGENTCARD, grant number LSHG-CT-2006-037683]. We thank the patients for agreeing to participate in the study. We thank Nour Moukalled for her help with subject recruitment and data collection. We thank the Rafic Hariri University Hospital and “Centre Hospitalier du Nord” for their collaboration and support. The FGENTCARD Consortium: Dominique Gauguier, The Wellcome Trust Centre for Human Genetics, University of Oxford, UK; Mark Lathrop, Jörg Hager, CEA-Genomics Institute, Centre National de Génotypage, Evry, France; Jeremy K. Nicholson, Imperial College London, UK; Pierre Zalloua, Lebanese American University, School of Medicine, Beirut, Lebanon; Ulla Grove Sidelmann, Novo Nordisk, Måløv, Denmark; Frank Bonner, Metabometrix Ltd, London, UK. Publisher Copyright: © 2014, Milane et al.; licensee Springer.

PY - 2014/9/24

Y1 - 2014/9/24

N2 - Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001).In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated.The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population.

AB - Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001).In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated.The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population.

KW - Antihypertensive drugs

KW - Coronary artery disease (CAD)

KW - Hypertension

KW - Lebanese population

KW - Risk factors

KW - Therapeutic lifestyle changes

UR - https://www.scopus.com/pages/publications/84933503510

U2 - 10.1186/2193-1801-3-533

DO - 10.1186/2193-1801-3-533

M3 - Article

AN - SCOPUS:84933503510

SN - 2193-1801

VL - 3

SP - 1

EP - 7

JO - SpringerPlus

JF - SpringerPlus

IS - 1

M1 - 533

ER -