Association of hypertension with coronary artery disease onset in the Lebanese population

Aline Milane, Jad Abdallah, Roy Kanbar, Georges Khazen, Michella Ghassibe-Sabbagh, Angelique K. Salloum, Sonia Youhanna, Aline Saad, Hamid El Bayeh, Elie Chammas, Daniel E. Platt, Jörg Hager, Dominique Gauguier, Pierre Zalloua, Antoine Abchee

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001).

In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.

This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated.

The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population.

Original languageBritish English
Article number533
Pages (from-to)1-7
Number of pages7
JournalSpringerPlus
Volume3
Issue number1
DOIs
StatePublished - 24 Sep 2014

Keywords

  • Antihypertensive drugs
  • Coronary artery disease (CAD)
  • Hypertension
  • Lebanese population
  • Risk factors
  • Therapeutic lifestyle changes

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