Assessment of metal implant induced artefacts using photon counting spectral CT

Maya Rajeswari Amma; Anthony P.H. Butler; Aamir Y. Raja; Benjamin Bamford; Philip Butler; E. Peter Walker; Aysouda Matanaghi; Sikiru A. Adebileje; Nigel Anderson; Marzieh Anjomrouz; Fatemeh Asghariomabad; Ali Atharifard; Stephen T. Bell; Srinidhi Bheesette; Alexander I. Chernoglazov; Tara Dalefield; Neils J.A. De Ruiter; Neryda Duncan; Robert M.N. Doesburg; Steven Gieseg; Brian P. Goulter; Steven D. Alexander; Sam Gurney; Joseph L. Healy; Peter J. Hilton; Shishir Dahal; Pierre Carbonez; Jerome Damet; Claire Chambers; Praveenkumar Kanithi; Tracy Kirkbride; Stuart P. Lansley; Chiara Lowe; V. B.H. Mandalika; Emmanuel Marfo; Mahdieh Moghiseh; David Palmer; Raj K. Panta; Hannah M. Prebble; Mohsen Ramyar; Peter Renaud; Nanette Schleich; Emily Searle; Muhammed Shamshad; Jereena S. Sheeja; Rayhan Uddin; Lieza Vanden Broeke; V. S. Vivek; Manoj Wijesooriya; Michael F. Walsh; Kenzie Baer; Seamus Tredinnick; Tim Woodfield

doi:10.1117/12.2531003

Assessment of metal implant induced artefacts using photon counting spectral CT

Maya Rajeswari Amma, Anthony P.H. Butler, Aamir Y. Raja, Benjamin Bamford, Philip Butler, E. Peter Walker, Aysouda Matanaghi, Sikiru A. Adebileje, Nigel Anderson, Marzieh Anjomrouz, Fatemeh Asghariomabad, Ali Atharifard, Stephen T. Bell, Srinidhi Bheesette, Alexander I. Chernoglazov, Tara Dalefield, Neils J.A. De Ruiter, Neryda Duncan, Robert M.N. Doesburg, Steven GiesegBrian P. Goulter, Steven D. Alexander, Sam Gurney, Joseph L. Healy, Peter J. Hilton, Shishir Dahal, Pierre Carbonez, Jerome Damet, Claire Chambers, Praveenkumar Kanithi, Tracy Kirkbride, Stuart P. Lansley, Chiara Lowe, V. B.H. Mandalika, Emmanuel Marfo, Mahdieh Moghiseh, David Palmer, Raj K. Panta, Hannah M. Prebble, Mohsen Ramyar, Peter Renaud, Nanette Schleich, Emily Searle, Muhammed Shamshad, Jereena S. Sheeja, Rayhan Uddin, Lieza Vanden Broeke, V. S. Vivek, Manoj Wijesooriya, Michael F. Walsh, Kenzie Baer, Seamus Tredinnick, Tim Woodfield

Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

The aim is to perform qualitative and quantitative assessment of metal induced artefacts of small titanium biomaterials using photon counting spectral CT. The energy binning feature of some photon counting detectors enables the measured spectrum to be segmented into low, mid and high energy bins in a single exposure. In this study, solid and porous titanium implants submerged in different concentrations of calcium solution were scanned using the small animal MARS photon counting spectral scanner equipped with a polyenergetic X-ray source operated at 118 kVp. Five narrow energy bins (7-45 keV, 45-55 keV, 55-65 keV, 65-75 keV and 75-118 keV) in charge summing mode were utilised. Images were evaluated in the energy domain (spectroscopic images) as well as material domain (material segmentation and quantification). Results show that calcium solution outside titanium implants can be accurately quantified. However, there was an overestimation of calcium within the pores of the scaffold. This information is critical as it can severely limit the assessment of bone ingrowth within metal structures. The energy binning feature of the spectral scanner was exploited and a correction factor, based on calcium concentrations adjacent to and within metal structures, was used to minimise the variation. Qualitative and quantitative evaluation of bone density and morphology with and without titanium screw shows that photon counting spectral CT can assess bone-metal interface with less pronounced artefacts. Quantification of bone growth in and around the implants would help in orthopaedic applications to determine the effectiveness of implant treatment and assessment of fracture healing.

Original language	British English
Title of host publication	Developments in X-Ray Tomography XII
Editors	Bert Muller, Ge Wang
Publisher	SPIE
ISBN (Electronic)	9781510629196
DOIs	https://doi.org/10.1117/12.2531003
State	Published - 2019
Event	12th SPIE Conference on Developments in X-Ray Tomography 2019 - San Diego, United States Duration: 13 Aug 2019 → 15 Aug 2019

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11113
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	12th SPIE Conference on Developments in X-Ray Tomography 2019
Country/Territory	United States
City	San Diego
Period	13/08/19 → 15/08/19

Keywords

Bone density
Bone morphology
Charge summing mode
Implant loosening
Metal artefacts
Orthopaedic applications
Osteolysis
Photon counting spectral CT
Titanium biomaterials

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10.1117/12.2531003

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Rajeswari Amma, M., Butler, A. P. H., Raja, A. Y., Bamford, B., Butler, P., Walker, E. P., Matanaghi, A., Adebileje, S. A., Anderson, N., Anjomrouz, M., Asghariomabad, F., Atharifard, A., Bell, S. T., Bheesette, S., Chernoglazov, A. I., Dalefield, T., De Ruiter, N. J. A., Duncan, N., Doesburg, R. M. N., ... Woodfield, T. (2019). Assessment of metal implant induced artefacts using photon counting spectral CT. In B. Muller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Article 111131D (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11113). SPIE. https://doi.org/10.1117/12.2531003

@inproceedings{bd73d9dcafdd44f3841456fdd7c199d7,

title = "Assessment of metal implant induced artefacts using photon counting spectral CT",

abstract = "The aim is to perform qualitative and quantitative assessment of metal induced artefacts of small titanium biomaterials using photon counting spectral CT. The energy binning feature of some photon counting detectors enables the measured spectrum to be segmented into low, mid and high energy bins in a single exposure. In this study, solid and porous titanium implants submerged in different concentrations of calcium solution were scanned using the small animal MARS photon counting spectral scanner equipped with a polyenergetic X-ray source operated at 118 kVp. Five narrow energy bins (7-45 keV, 45-55 keV, 55-65 keV, 65-75 keV and 75-118 keV) in charge summing mode were utilised. Images were evaluated in the energy domain (spectroscopic images) as well as material domain (material segmentation and quantification). Results show that calcium solution outside titanium implants can be accurately quantified. However, there was an overestimation of calcium within the pores of the scaffold. This information is critical as it can severely limit the assessment of bone ingrowth within metal structures. The energy binning feature of the spectral scanner was exploited and a correction factor, based on calcium concentrations adjacent to and within metal structures, was used to minimise the variation. Qualitative and quantitative evaluation of bone density and morphology with and without titanium screw shows that photon counting spectral CT can assess bone-metal interface with less pronounced artefacts. Quantification of bone growth in and around the implants would help in orthopaedic applications to determine the effectiveness of implant treatment and assessment of fracture healing.",

keywords = "Bone density, Bone morphology, Charge summing mode, Implant loosening, Metal artefacts, Orthopaedic applications, Osteolysis, Photon counting spectral CT, Titanium biomaterials",

author = "{Rajeswari Amma}, Maya and Butler, {Anthony P.H.} and Raja, {Aamir Y.} and Benjamin Bamford and Philip Butler and Walker, {E. Peter} and Aysouda Matanaghi and Adebileje, {Sikiru A.} and Nigel Anderson and Marzieh Anjomrouz and Fatemeh Asghariomabad and Ali Atharifard and Bell, {Stephen T.} and Srinidhi Bheesette and Chernoglazov, {Alexander I.} and Tara Dalefield and {De Ruiter}, {Neils J.A.} and Neryda Duncan and Doesburg, {Robert M.N.} and Steven Gieseg and Goulter, {Brian P.} and Alexander, {Steven D.} and Sam Gurney and Healy, {Joseph L.} and Hilton, {Peter J.} and Shishir Dahal and Pierre Carbonez and Jerome Damet and Claire Chambers and Praveenkumar Kanithi and Tracy Kirkbride and Lansley, {Stuart P.} and Chiara Lowe and Mandalika, {V. B.H.} and Emmanuel Marfo and Mahdieh Moghiseh and David Palmer and Panta, {Raj K.} and Prebble, {Hannah M.} and Mohsen Ramyar and Peter Renaud and Nanette Schleich and Emily Searle and Muhammed Shamshad and Sheeja, {Jereena S.} and Rayhan Uddin and {Vanden Broeke}, Lieza and Vivek, {V. S.} and Manoj Wijesooriya and Walsh, {Michael F.} and Kenzie Baer and Seamus Tredinnick and Tim Woodfield",

note = "Funding Information: This project was funded by the Ministry of Business, Innovation and Employment (MBIE), New Zealand under contract number UOCX1404, by MARS Bioimaging Ltd and the Ministry of Education through the MedTech CoRE. The authors would like to acknowledge the Medipix2, Medipix3 and Medipix4 collaborations. Also, we opportunity to acknowledge the generous support of the MARS Collaboration. Funding Information: This project was funded by the Ministry of Business, Innovation and Employment (MBIE), New Zealand under contract number UOCX1404, by MARS Bioimaging Ltd and the Ministry of Education through the MedTech CoRE. The authors would like to acknowledge the Medipix2, Medipix3 and Medipix4 collaborations. Also, we would like to take this opportunity to acknowledge the generous support of the MARS Collaboration. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; 12th SPIE Conference on Developments in X-Ray Tomography 2019 ; Conference date: 13-08-2019 Through 15-08-2019",

year = "2019",

doi = "10.1117/12.2531003",

language = "British English",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

editor = "Bert Muller and Ge Wang",

booktitle = "Developments in X-Ray Tomography XII",

address = "United States",

}

Rajeswari Amma, M, Butler, APH, Raja, AY, Bamford, B, Butler, P, Walker, EP, Matanaghi, A, Adebileje, SA, Anderson, N, Anjomrouz, M, Asghariomabad, F, Atharifard, A, Bell, ST, Bheesette, S, Chernoglazov, AI, Dalefield, T, De Ruiter, NJA, Duncan, N, Doesburg, RMN, Gieseg, S, Goulter, BP, Alexander, SD, Gurney, S, Healy, JL, Hilton, PJ, Dahal, S, Carbonez, P, Damet, J, Chambers, C, Kanithi, P, Kirkbride, T, Lansley, SP, Lowe, C, Mandalika, VBH, Marfo, E, Moghiseh, M, Palmer, D, Panta, RK, Prebble, HM, Ramyar, M, Renaud, P, Schleich, N, Searle, E, Shamshad, M, Sheeja, JS, Uddin, R, Vanden Broeke, L, Vivek, VS, Wijesooriya, M, Walsh, MF, Baer, K, Tredinnick, S & Woodfield, T 2019, Assessment of metal implant induced artefacts using photon counting spectral CT. in B Muller & G Wang (eds), Developments in X-Ray Tomography XII., 111131D, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11113, SPIE, 12th SPIE Conference on Developments in X-Ray Tomography 2019, San Diego, United States, 13/08/19. https://doi.org/10.1117/12.2531003

Assessment of metal implant induced artefacts using photon counting spectral CT. / Rajeswari Amma, Maya; Butler, Anthony P.H.; Raja, Aamir Y. et al.
Developments in X-Ray Tomography XII. ed. / Bert Muller; Ge Wang. SPIE, 2019. 111131D (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11113).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Assessment of metal implant induced artefacts using photon counting spectral CT

AU - Rajeswari Amma, Maya

AU - Butler, Anthony P.H.

AU - Raja, Aamir Y.

AU - Bamford, Benjamin

AU - Butler, Philip

AU - Walker, E. Peter

AU - Matanaghi, Aysouda

AU - Adebileje, Sikiru A.

AU - Anderson, Nigel

AU - Anjomrouz, Marzieh

AU - Asghariomabad, Fatemeh

AU - Atharifard, Ali

AU - Bell, Stephen T.

AU - Bheesette, Srinidhi

AU - Chernoglazov, Alexander I.

AU - Dalefield, Tara

AU - De Ruiter, Neils J.A.

AU - Duncan, Neryda

AU - Doesburg, Robert M.N.

AU - Gieseg, Steven

AU - Goulter, Brian P.

AU - Alexander, Steven D.

AU - Gurney, Sam

AU - Healy, Joseph L.

AU - Hilton, Peter J.

AU - Dahal, Shishir

AU - Carbonez, Pierre

AU - Damet, Jerome

AU - Chambers, Claire

AU - Kanithi, Praveenkumar

AU - Kirkbride, Tracy

AU - Lansley, Stuart P.

AU - Lowe, Chiara

AU - Mandalika, V. B.H.

AU - Marfo, Emmanuel

AU - Moghiseh, Mahdieh

AU - Palmer, David

AU - Panta, Raj K.

AU - Prebble, Hannah M.

AU - Ramyar, Mohsen

AU - Renaud, Peter

AU - Schleich, Nanette

AU - Searle, Emily

AU - Shamshad, Muhammed

AU - Sheeja, Jereena S.

AU - Uddin, Rayhan

AU - Vanden Broeke, Lieza

AU - Vivek, V. S.

AU - Wijesooriya, Manoj

AU - Walsh, Michael F.

AU - Baer, Kenzie

AU - Tredinnick, Seamus

AU - Woodfield, Tim

N1 - Funding Information: This project was funded by the Ministry of Business, Innovation and Employment (MBIE), New Zealand under contract number UOCX1404, by MARS Bioimaging Ltd and the Ministry of Education through the MedTech CoRE. The authors would like to acknowledge the Medipix2, Medipix3 and Medipix4 collaborations. Also, we opportunity to acknowledge the generous support of the MARS Collaboration. Funding Information: This project was funded by the Ministry of Business, Innovation and Employment (MBIE), New Zealand under contract number UOCX1404, by MARS Bioimaging Ltd and the Ministry of Education through the MedTech CoRE. The authors would like to acknowledge the Medipix2, Medipix3 and Medipix4 collaborations. Also, we would like to take this opportunity to acknowledge the generous support of the MARS Collaboration. Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2019

Y1 - 2019

N2 - The aim is to perform qualitative and quantitative assessment of metal induced artefacts of small titanium biomaterials using photon counting spectral CT. The energy binning feature of some photon counting detectors enables the measured spectrum to be segmented into low, mid and high energy bins in a single exposure. In this study, solid and porous titanium implants submerged in different concentrations of calcium solution were scanned using the small animal MARS photon counting spectral scanner equipped with a polyenergetic X-ray source operated at 118 kVp. Five narrow energy bins (7-45 keV, 45-55 keV, 55-65 keV, 65-75 keV and 75-118 keV) in charge summing mode were utilised. Images were evaluated in the energy domain (spectroscopic images) as well as material domain (material segmentation and quantification). Results show that calcium solution outside titanium implants can be accurately quantified. However, there was an overestimation of calcium within the pores of the scaffold. This information is critical as it can severely limit the assessment of bone ingrowth within metal structures. The energy binning feature of the spectral scanner was exploited and a correction factor, based on calcium concentrations adjacent to and within metal structures, was used to minimise the variation. Qualitative and quantitative evaluation of bone density and morphology with and without titanium screw shows that photon counting spectral CT can assess bone-metal interface with less pronounced artefacts. Quantification of bone growth in and around the implants would help in orthopaedic applications to determine the effectiveness of implant treatment and assessment of fracture healing.

AB - The aim is to perform qualitative and quantitative assessment of metal induced artefacts of small titanium biomaterials using photon counting spectral CT. The energy binning feature of some photon counting detectors enables the measured spectrum to be segmented into low, mid and high energy bins in a single exposure. In this study, solid and porous titanium implants submerged in different concentrations of calcium solution were scanned using the small animal MARS photon counting spectral scanner equipped with a polyenergetic X-ray source operated at 118 kVp. Five narrow energy bins (7-45 keV, 45-55 keV, 55-65 keV, 65-75 keV and 75-118 keV) in charge summing mode were utilised. Images were evaluated in the energy domain (spectroscopic images) as well as material domain (material segmentation and quantification). Results show that calcium solution outside titanium implants can be accurately quantified. However, there was an overestimation of calcium within the pores of the scaffold. This information is critical as it can severely limit the assessment of bone ingrowth within metal structures. The energy binning feature of the spectral scanner was exploited and a correction factor, based on calcium concentrations adjacent to and within metal structures, was used to minimise the variation. Qualitative and quantitative evaluation of bone density and morphology with and without titanium screw shows that photon counting spectral CT can assess bone-metal interface with less pronounced artefacts. Quantification of bone growth in and around the implants would help in orthopaedic applications to determine the effectiveness of implant treatment and assessment of fracture healing.

KW - Bone density

KW - Bone morphology

KW - Charge summing mode

KW - Implant loosening

KW - Metal artefacts

KW - Orthopaedic applications

KW - Osteolysis

KW - Photon counting spectral CT

KW - Titanium biomaterials

UR - http://www.scopus.com/inward/record.url?scp=85077789757&partnerID=8YFLogxK

U2 - 10.1117/12.2531003

DO - 10.1117/12.2531003

M3 - Conference contribution

AN - SCOPUS:85077789757

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Developments in X-Ray Tomography XII

A2 - Muller, Bert

A2 - Wang, Ge

PB - SPIE

T2 - 12th SPIE Conference on Developments in X-Ray Tomography 2019

Y2 - 13 August 2019 through 15 August 2019

ER -

Assessment of metal implant induced artefacts using photon counting spectral CT

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