@inproceedings{ac0729cc9f574051837157a44d29d508,
title = "Assessment of autonomic neurodevelopment in the mouse fetuses by using fetal electrocardiography",
abstract = "Fetal Electrocardiography (FECG) offers unique capabilities for assessment of beat-to-beat fetal heart rate (FHR) and fetal heart rate variability (FHRV), which are indirect markers of autonomic nervous system, its development. In this study the fetal ECG signals, FHR and FHRV are successfully recorded to assess the neurodevelopment in fetal mice in the second and third trimester from days 12.5 to 18.5 by using direct insertion of fetal ECG electrodes in the uterine. FHR increases from day 12.5 till 15.5 reaching a plateau and then shows a sudden increase on the day 18.5. Development of fetal increasing heart rate variability (FHRV) is clearly evident from the results. Short term FHRV (RMSSD) corresponding to parasympathetic nervous system activity and long term FHRV (SDNN) corresponding to sympathetic and parasympathetic nervous system activities increases till day 16.5 and then decreases from day 17.5. The increases in large fluctuations were noticed on days 17.5 and 18.5, which were thought to have caused by uterine contractions before delivery. The ability to assess FHR and FHRV in fetal mice makes a valuable tool for neurodevelopment research in perinatal medicine.",
author = "Khandoker, {Ahsan H.} and Khoori, {Thuraia Al} and Takuya Ito and Rika Sugibayashi and Yoshitaka Kimura",
note = "Funding Information: This study was supported by Translational Research Network Program (project code: J150000293) form The Japan Agency for Medical Research and Development (AMED) Publisher Copyright: {\textcopyright} 2016 IEEE.; 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 ; Conference date: 16-08-2016 Through 20-08-2016",
year = "2016",
month = oct,
day = "13",
doi = "10.1109/EMBC.2016.7591349",
language = "British English",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "2954--2957",
booktitle = "2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016",
address = "United States",
}