Assessing sympatho-vagal balance in schizophrenia through tone-entropy analysis

Ahsan H. Khandoker, Mami Fujibayashi, Toshio Moritani, Marimuthu Palaniswami

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


Although schizophrenia patients more likely commit suicide, however, more than two thirds of patients with schizophrenia, compared with approximately one-half in the general population, die of coronary heart disease (CHD). The aim of this study, therefore, is to determine whether Tone-Entropy (T-E) analysis method can determine how and to what extend the symaptho-vagal balance is altered with the severity of psychiatric disorders as determined by Global Assessment of Functioning (GAF) scale. Tone represents sympathovagal balance and entropy, the autonomic regularity activity. This study included 32 high-GAF, 32 low-GAF and 118 healthy control subjects. Evaluated tones and are significantly (p<0.01) different among three groups. The significantly higher tone and lower entropy in the low- GAF group might suggest altered sympatho-vagal balance which could predict increasing risks of cardiovascular death.

Original languageBritish English
Title of host publicationComputing in Cardiology 2010, CinC 2010
Number of pages4
StatePublished - 2010
EventComputing in Cardiology 2010, CinC 2010 - Belfast, United Kingdom
Duration: 26 Sep 201029 Sep 2010

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


ConferenceComputing in Cardiology 2010, CinC 2010
Country/TerritoryUnited Kingdom


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