Aqueous two-phase flotation for extraction of andrographolide from Andrographis Paniculata

Wan Yi Choy; Chok Yau Chung; Pei Zhi Lim; Videsh Al Sagindharan; Sze Ying Lee; Pau Loke Show; Hon Loong Lam

doi:10.3303/CET1545180

Aqueous two-phase flotation for extraction of andrographolide from Andrographis Paniculata

Wan Yi Choy, Chok Yau Chung, Pei Zhi Lim, Videsh Al Sagindharan, Sze Ying Lee, Pau Loke Show, Hon Loong Lam

Chemical and Petroleum Engineering

University of Nottingham Malaysia

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

This paper was presented about the extraction of bioactive ingredient that is beneficial towards skin and human health from herbs. Andrographis Paniculata was used for this paper to undergo optimisation of extraction method by modern and novel extraction technique which is aqueous two-phase flotation (ATPF). ATPF extraction is rapid and has simple extraction procedures, resulting in achieving the target yield in least time and energy saving. Under comparison between sonication, soxhlet, aqueous two-phase system (ATPS), and ATPF extraction techniques, ATPF had been chosen as the more effective extraction method for Andrographis Paniculata. The optimised ATPF system was able to yield 5.85 % of Andrographolide with the ATPF's operating condition set to 38.96 wt% methanol as top phase, 12 wt% di-potassium hydrogen phosphate as bottom phase, 30 min of flotation time, 50 mL/min nitrogen gas flowrate, and 0.75 g of crude load at ambient temperature (25 ± 1 °C).

Original language	British English
Title of host publication	Chemical Engineering Transactions
Editors	Xia Liu, Petar Sabev Varbanov, Jiri Jaromir Klemes, Sharifah Rafidah Wan Alwi, Jun Yow Yong
Pages	1075-1080
Number of pages	6
Volume	45
ISBN (Electronic)	9788895608365
DOIs	https://doi.org/10.3303/CET1545180
State	Published - Oct 2015

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title = "Aqueous two-phase flotation for extraction of andrographolide from Andrographis Paniculata",

abstract = "This paper was presented about the extraction of bioactive ingredient that is beneficial towards skin and human health from herbs. Andrographis Paniculata was used for this paper to undergo optimisation of extraction method by modern and novel extraction technique which is aqueous two-phase flotation (ATPF). ATPF extraction is rapid and has simple extraction procedures, resulting in achieving the target yield in least time and energy saving. Under comparison between sonication, soxhlet, aqueous two-phase system (ATPS), and ATPF extraction techniques, ATPF had been chosen as the more effective extraction method for Andrographis Paniculata. The optimised ATPF system was able to yield 5.85 % of Andrographolide with the ATPF's operating condition set to 38.96 wt% methanol as top phase, 12 wt% di-potassium hydrogen phosphate as bottom phase, 30 min of flotation time, 50 mL/min nitrogen gas flowrate, and 0.75 g of crude load at ambient temperature (25 ± 1 °C).",

author = "Choy, {Wan Yi} and Chung, {Chok Yau} and Lim, {Pei Zhi} and {Al Sagindharan}, Videsh and Lee, {Sze Ying} and Show, {Pau Loke} and Lam, {Hon Loong}",

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year = "2015",

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doi = "10.3303/CET1545180",

language = "British English",

volume = "45",

pages = "1075--1080",

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booktitle = "Chemical Engineering Transactions",

}

Aqueous two-phase flotation for extraction of andrographolide from Andrographis Paniculata. / Choy, Wan Yi; Chung, Chok Yau; Lim, Pei Zhi et al.
Chemical Engineering Transactions. ed. / Xia Liu; Petar Sabev Varbanov; Jiri Jaromir Klemes; Sharifah Rafidah Wan Alwi; Jun Yow Yong. Vol. 45 2015. p. 1075-1080.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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T1 - Aqueous two-phase flotation for extraction of andrographolide from Andrographis Paniculata

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AU - Chung, Chok Yau

AU - Lim, Pei Zhi

AU - Al Sagindharan, Videsh

AU - Lee, Sze Ying

AU - Show, Pau Loke

AU - Lam, Hon Loong

PY - 2015/10

Y1 - 2015/10

N2 - This paper was presented about the extraction of bioactive ingredient that is beneficial towards skin and human health from herbs. Andrographis Paniculata was used for this paper to undergo optimisation of extraction method by modern and novel extraction technique which is aqueous two-phase flotation (ATPF). ATPF extraction is rapid and has simple extraction procedures, resulting in achieving the target yield in least time and energy saving. Under comparison between sonication, soxhlet, aqueous two-phase system (ATPS), and ATPF extraction techniques, ATPF had been chosen as the more effective extraction method for Andrographis Paniculata. The optimised ATPF system was able to yield 5.85 % of Andrographolide with the ATPF's operating condition set to 38.96 wt% methanol as top phase, 12 wt% di-potassium hydrogen phosphate as bottom phase, 30 min of flotation time, 50 mL/min nitrogen gas flowrate, and 0.75 g of crude load at ambient temperature (25 ± 1 °C).

AB - This paper was presented about the extraction of bioactive ingredient that is beneficial towards skin and human health from herbs. Andrographis Paniculata was used for this paper to undergo optimisation of extraction method by modern and novel extraction technique which is aqueous two-phase flotation (ATPF). ATPF extraction is rapid and has simple extraction procedures, resulting in achieving the target yield in least time and energy saving. Under comparison between sonication, soxhlet, aqueous two-phase system (ATPS), and ATPF extraction techniques, ATPF had been chosen as the more effective extraction method for Andrographis Paniculata. The optimised ATPF system was able to yield 5.85 % of Andrographolide with the ATPF's operating condition set to 38.96 wt% methanol as top phase, 12 wt% di-potassium hydrogen phosphate as bottom phase, 30 min of flotation time, 50 mL/min nitrogen gas flowrate, and 0.75 g of crude load at ambient temperature (25 ± 1 °C).

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ER -

Aqueous two-phase flotation for extraction of andrographolide from Andrographis Paniculata

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