TY - JOUR
T1 - Appraising the evolving landscape of protease inhibition in osteoarthritis
T2 - Osteoarthritis
AU - Rai, Muhammad Farooq
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2025/3
Y1 - 2025/3
N2 - The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decades of research on protease inhibitors, however, the transition from preclinical promise to clinical success remains elusive, underscoring the urgent need to critically appraise the challenges and limitations inherent in preclinical studies.
AB - The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decades of research on protease inhibitors, however, the transition from preclinical promise to clinical success remains elusive, underscoring the urgent need to critically appraise the challenges and limitations inherent in preclinical studies.
UR - https://www.scopus.com/pages/publications/85211782663
U2 - 10.1038/s41584-024-01198-2
DO - 10.1038/s41584-024-01198-2
M3 - Comment/debate
C2 - 39663464
AN - SCOPUS:85211782663
SN - 1759-4790
VL - 21
SP - 131
EP - 132
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
IS - 3
ER -