Applications of viral nanoparticles in medicine

Ibrahim Yildiz, Sourabh Shukla, Nicole F. Steinmetz

Research output: Contribution to journalReview articlepeer-review

267 Scopus citations

Abstract

Several nanoparticle platforms are currently being developed for applications in medicine, including both synthetic materials and naturally occurring bionanomaterials such as viral nanoparticles (VNPs) and their genome-free counterparts, virus-like particles (VLPs). A broad range of genetic and chemical engineering methods have been established that allow VNP/VLP formulations to carry large payloads of imaging reagents or drugs. Furthermore, targeted VNPs and VLPs can be generated by including peptide ligands on the particle surface. In this article, we highlight state-of-the-art virus engineering principles and discuss recent advances that bring potential biomedical applications a step closer. Viral nanotechnology has now come of age and it will not be long before these formulations assume a prominent role in the clinic.

Original languageBritish English
Pages (from-to)901-908
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume22
Issue number6
DOIs
StatePublished - Dec 2011

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