TY - JOUR
T1 - Antimicrobial hydroxyapatite reinforced-polyelectrolyte complex nanofibers with long-term controlled release activity for potential wound dressing application
AU - Wang, Jingyuan
AU - Cai, Ning
AU - Chan, Vincent
AU - Zeng, Huan
AU - Shi, Hongrui
AU - Xue, Yanan
AU - Yu, Faquan
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (Grant No. 22078251 and 51808414 ), the Research Project of Hubei Provincial Department of Education of China (Grant No. D20191504 ), Outstanding Young and Middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province : " Biomass chemical technologies and materials " (Grant No. T201908 ) as well as the Graduate Innovative Fund of Wuhan Institute of Technology (Grant No. CX2019001 ).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/5
Y1 - 2021/9/5
N2 - The prevention of wound infection has remained to be a critical step for facilitating wound healing following the application of wound dressing. To overcome such challenge, nano-hydroxyapatite (n-HAP) with high specific surface area, excellent biocompatibility, high mechanical strength and strong adsorption capacity was developed into a novel controlled release system for antimicrobial therapy. In general, n-HAP was loaded with a model antibiotic, tetracycline hydrochloride and was subsequently encapsulated inside chitosan/gelatin polyelectrolyte complex (PEC) nanofibers with a typical core-shell geometry. Firstly, the encapsulation of either tetracycline hydrochloride (TCH) or n-HAP led to the slight shrinkage of fiber diameter and enhancement in the thermotropic stability of PEC nanofiber. Secondly, the good water retention and air transmission properties of PEC was not impaired by the inclusion of n-HAP and TCH. Finally, the n-HAP reinforced PEC nanofiber membrane with encapsulated tetracycline hydrochloride has achieved the effect of long-term drug release, thereby improving the antibacterial efficacy against S. aureus, a common pathogen. Based on the good water retention, high rigidity, long term sustained drug release and prolonged antibacterial therapeutic efficacy, n-HAP reinforced PEC nanofiber membranes will serve as a promising platform for developing into novel antimicrobial wound dressings.
AB - The prevention of wound infection has remained to be a critical step for facilitating wound healing following the application of wound dressing. To overcome such challenge, nano-hydroxyapatite (n-HAP) with high specific surface area, excellent biocompatibility, high mechanical strength and strong adsorption capacity was developed into a novel controlled release system for antimicrobial therapy. In general, n-HAP was loaded with a model antibiotic, tetracycline hydrochloride and was subsequently encapsulated inside chitosan/gelatin polyelectrolyte complex (PEC) nanofibers with a typical core-shell geometry. Firstly, the encapsulation of either tetracycline hydrochloride (TCH) or n-HAP led to the slight shrinkage of fiber diameter and enhancement in the thermotropic stability of PEC nanofiber. Secondly, the good water retention and air transmission properties of PEC was not impaired by the inclusion of n-HAP and TCH. Finally, the n-HAP reinforced PEC nanofiber membrane with encapsulated tetracycline hydrochloride has achieved the effect of long-term drug release, thereby improving the antibacterial efficacy against S. aureus, a common pathogen. Based on the good water retention, high rigidity, long term sustained drug release and prolonged antibacterial therapeutic efficacy, n-HAP reinforced PEC nanofiber membranes will serve as a promising platform for developing into novel antimicrobial wound dressings.
KW - Antimicrobial
KW - Drug release
KW - Nano-hydroxyapatite
KW - Nanofibers
KW - Polyelectrolyte complex
UR - http://www.scopus.com/inward/record.url?scp=85105799428&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2021.126722
DO - 10.1016/j.colsurfa.2021.126722
M3 - Article
AN - SCOPUS:85105799428
SN - 0927-7757
VL - 624
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
M1 - 126722
ER -