Antimicrobial efficacy of green synthesized drug blended silver nanoparticles against dental caries and periodontal disease causing microorganisms

R. Emmanuel, Selvakumar Palanisamy, Shen Ming Chen, K. Chelladurai, S. Padmavathy, M. Saravanan, P. Prakash, M. Ajmal Ali, Fahad M.A. Al-Hemaid

    Research output: Contribution to journalArticlepeer-review

    128 Scopus citations

    Abstract

    Development of biologically inspired green synthesis of silver nanoparticles is evolving into an important branch of nano-biotechnology. In the present investigation, we report the green synthesis of silver nanoparticles (AgNPs) employing the leaf extract of Justicia glauca.Water-soluble organics present in the leaf extract aremainly responsible for the reduction of silver nitrate (AgNO3) solution to AgNPs. The AgNPs are 10-20nmin dimensions as determined by TEM images. The antimicrobial activities of green synthesized AgNPs and drug blended AgNPs have been evaluated against the dental caries and periodontal disease causing microorganisms such as Streptococcus mutans, Staphylococcus aureus, Lactobacillus acidophilus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The AgNPs and drug blended AgNPs show a significant antibacterial and antifungal activity. Minimum inhibitory concentration (MIC) value of AgNPs determined against the selected dental caries and periodontal disease causing microorganisms are noticeable between the range of 25-75 μg/mL.

    Original languageBritish English
    Pages (from-to)374-379
    Number of pages6
    JournalMaterials Science and Engineering C
    Volume56
    Issue number1
    DOIs
    StatePublished - 2015

    Keywords

    • Silver nanoparticles justicia glauca antimicrobial activities dental caries periodontal disease

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