TY - JOUR
T1 - Antimicrobial efficacy of green synthesized drug blended silver nanoparticles against dental caries and periodontal disease causing microorganisms
AU - Emmanuel, R.
AU - Palanisamy, Selvakumar
AU - Chen, Shen Ming
AU - Chelladurai, K.
AU - Padmavathy, S.
AU - Saravanan, M.
AU - Prakash, P.
AU - Ali, M. Ajmal
AU - Al-Hemaid, Fahad M.A.
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Development of biologically inspired green synthesis of silver nanoparticles is evolving into an important branch of nano-biotechnology. In the present investigation, we report the green synthesis of silver nanoparticles (AgNPs) employing the leaf extract of Justicia glauca.Water-soluble organics present in the leaf extract aremainly responsible for the reduction of silver nitrate (AgNO3) solution to AgNPs. The AgNPs are 10-20nmin dimensions as determined by TEM images. The antimicrobial activities of green synthesized AgNPs and drug blended AgNPs have been evaluated against the dental caries and periodontal disease causing microorganisms such as Streptococcus mutans, Staphylococcus aureus, Lactobacillus acidophilus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The AgNPs and drug blended AgNPs show a significant antibacterial and antifungal activity. Minimum inhibitory concentration (MIC) value of AgNPs determined against the selected dental caries and periodontal disease causing microorganisms are noticeable between the range of 25-75 μg/mL.
AB - Development of biologically inspired green synthesis of silver nanoparticles is evolving into an important branch of nano-biotechnology. In the present investigation, we report the green synthesis of silver nanoparticles (AgNPs) employing the leaf extract of Justicia glauca.Water-soluble organics present in the leaf extract aremainly responsible for the reduction of silver nitrate (AgNO3) solution to AgNPs. The AgNPs are 10-20nmin dimensions as determined by TEM images. The antimicrobial activities of green synthesized AgNPs and drug blended AgNPs have been evaluated against the dental caries and periodontal disease causing microorganisms such as Streptococcus mutans, Staphylococcus aureus, Lactobacillus acidophilus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The AgNPs and drug blended AgNPs show a significant antibacterial and antifungal activity. Minimum inhibitory concentration (MIC) value of AgNPs determined against the selected dental caries and periodontal disease causing microorganisms are noticeable between the range of 25-75 μg/mL.
KW - Silver nanoparticles justicia glauca antimicrobial activities dental caries periodontal disease
UR - http://www.scopus.com/inward/record.url?scp=84973423599&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2015.06.033
DO - 10.1016/j.msec.2015.06.033
M3 - Article
C2 - 26249603
AN - SCOPUS:84973423599
SN - 0928-4931
VL - 56
SP - 374
EP - 379
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
IS - 1
ER -