Anti-arthritic Property of Sahacharadi Kashayam against Freund's Complete Adjuvant Induced Arthritis in Wistar Rats

P. Praveen Kumar, K. Prabhu, Mudiganti Ram Krishna Rao, Mallika Jain, K. Kalaivani, Shruthi Dinakar, Sampad Shil, N. Vijayalakshmi

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    Abstract

    Introduction: The available modern molecular drugs for the therapy of Rheumatoid arthritis are beset with several side effects and alternative drugs are urgently needed. The present investigation was performed to evaluate the anti-arthritic activity of Sahacharadi Kashayam (SK), an Ayurvedic formulation, against Freund's complete adjuvant (CFA) - induced arthritis in rats. Methods: In this experimental trial, SK was administered at doses of 0.5, 1.0 and 1.5 ml/kg body weight orally to adjuvant (CFA) induced arthritic rats. The anti-arthritic activity was evaluated by using paw volume, haematological parameters and arthritic biomarkers. The efficacy of the Kashayam was compared with the standard Leflunomide (10 mg/kg) drug. Results: Significant reduction in paw volume and thickness by SK (0.5 ml dose) has been found and there was considerably improvement in haematological parameters and arthritic markers in CFA rats till 14 days. After 14th day SK treatment with doses (1.0 and 1.5ml), however, reoccurrence of inflammation and pathological changes were observed in rats. Conclusion: The study clearly indicated the anti-arthritic role of SK. Future studies, however, are warranted to provide a new approach in relation to the therapeutic dose and treatment period of SK which may eventually lead to the development of a new category of the anti-arthritic agent.

    Original languageBritish English
    Pages (from-to)459-464
    Number of pages6
    JournalPharmacognosy Journal
    Volume12
    Issue number3
    DOIs
    StatePublished - May 2020

    Keywords

    • Anti-arthritic activity
    • Arthritis; biomarkers
    • Sahacharadi Kashayam

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