Amyloid precursor protein in Alzheimer's disease

Rupesh Maurya; Gargi Bhattacharjee; Khushal Khambhati; Nisarg Gohil; Priyanka Singh; Indra Mani; Dinh Toi Chu; Suresh Ramakrishna; Pau Loke Show; Vijai Singh

doi:10.1016/bs.pmbts.2022.09.006

Amyloid precursor protein in Alzheimer's disease

Rupesh Maurya, Gargi Bhattacharjee, Khushal Khambhati, Nisarg Gohil, Priyanka Singh, Indra Mani, Dinh Toi Chu, Suresh Ramakrishna, Pau Loke Show, Vijai Singh

Chemical and Petroleum Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Scopus citations

Abstract

Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity. It is encoded by the APP gene that is regulated by substrate presentation. APP is a precursor protein activated by proteolytic cleavage and thereby generating amyloid beta (Aβ) peptides which eventually form amyloid plaques that accumulate in Alzheimer's disease patients' brains. In this chapter, we highlight basic mechanism, structure, expression patterns and cleavage of amyloid plaques, and its diagnosis and potential treatment for Alzheimer's disease.

Original language	British English
Title of host publication	Receptor Endocytosis And Signalling In Health And Disease - Part B
Editors	Indra Mani, Vijai Singh
Publisher	Elsevier B.V.
Pages	261-270
Number of pages	10
ISBN (Print)	9780323955591
DOIs	https://doi.org/10.1016/bs.pmbts.2022.09.006
State	Published - Jan 2023

Publication series

Name	Progress in Molecular Biology and Translational Science
Volume	196
ISSN (Print)	1877-1173
ISSN (Electronic)	1878-0814

Keywords

Alzheimer's disease
Amyloid beta
Amyloid precursor protein
Diagnosis
Expression patterns

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10.1016/bs.pmbts.2022.09.006

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Maurya, R., Bhattacharjee, G., Khambhati, K., Gohil, N., Singh, P., Mani, I., Chu, D. T., Ramakrishna, S., Show, P. L., & Singh, V. (2023). Amyloid precursor protein in Alzheimer's disease. In I. Mani, & V. Singh (Eds.), Receptor Endocytosis And Signalling In Health And Disease - Part B (pp. 261-270). (Progress in Molecular Biology and Translational Science; Vol. 196). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2022.09.006

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abstract = "Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity. It is encoded by the APP gene that is regulated by substrate presentation. APP is a precursor protein activated by proteolytic cleavage and thereby generating amyloid beta (Aβ) peptides which eventually form amyloid plaques that accumulate in Alzheimer's disease patients' brains. In this chapter, we highlight basic mechanism, structure, expression patterns and cleavage of amyloid plaques, and its diagnosis and potential treatment for Alzheimer's disease.",

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author = "Rupesh Maurya and Gargi Bhattacharjee and Khushal Khambhati and Nisarg Gohil and Priyanka Singh and Indra Mani and Chu, {Dinh Toi} and Suresh Ramakrishna and Show, {Pau Loke} and Vijai Singh",

note = "Funding Information: N.G. and G.B. acknowledge the Indian Council of Medical Research of the Government of India for financial assistance as Senior Research Fellowship File No. 5/3/8/63/ITR-F/2020 and File No. 5/3/8/41/ITR-F/2022-ITR, respectively. P.S. gratefully acknowledge the Gujarat State Biotechnology Mission for financial assistance as Junior Research Fellowship (Project ID: 5LY45F). The financial assistance from National Research Foundation of Korea (2021M3A9H3015389) and the Korean Fund for Regenerative Medicine (KFRM) grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) (22A0304L1-01) to S.R. is acknowledged. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

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doi = "10.1016/bs.pmbts.2022.09.006",

language = "British English",

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series = "Progress in Molecular Biology and Translational Science",

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Maurya, R, Bhattacharjee, G, Khambhati, K, Gohil, N, Singh, P, Mani, I, Chu, DT, Ramakrishna, S, Show, PL & Singh, V 2023, Amyloid precursor protein in Alzheimer's disease. in I Mani & V Singh (eds), Receptor Endocytosis And Signalling In Health And Disease - Part B. Progress in Molecular Biology and Translational Science, vol. 196, Elsevier B.V., pp. 261-270. https://doi.org/10.1016/bs.pmbts.2022.09.006

Amyloid precursor protein in Alzheimer's disease. / Maurya, Rupesh; Bhattacharjee, Gargi; Khambhati, Khushal et al.
Receptor Endocytosis And Signalling In Health And Disease - Part B. ed. / Indra Mani; Vijai Singh. Elsevier B.V., 2023. p. 261-270 (Progress in Molecular Biology and Translational Science; Vol. 196).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Bhattacharjee, Gargi

AU - Khambhati, Khushal

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AU - Singh, Priyanka

AU - Mani, Indra

AU - Chu, Dinh Toi

AU - Ramakrishna, Suresh

AU - Show, Pau Loke

AU - Singh, Vijai

N1 - Funding Information: N.G. and G.B. acknowledge the Indian Council of Medical Research of the Government of India for financial assistance as Senior Research Fellowship File No. 5/3/8/63/ITR-F/2020 and File No. 5/3/8/41/ITR-F/2022-ITR, respectively. P.S. gratefully acknowledge the Gujarat State Biotechnology Mission for financial assistance as Junior Research Fellowship (Project ID: 5LY45F). The financial assistance from National Research Foundation of Korea (2021M3A9H3015389) and the Korean Fund for Regenerative Medicine (KFRM) grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) (22A0304L1-01) to S.R. is acknowledged. Publisher Copyright: © 2023 Elsevier Inc.

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N2 - Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity. It is encoded by the APP gene that is regulated by substrate presentation. APP is a precursor protein activated by proteolytic cleavage and thereby generating amyloid beta (Aβ) peptides which eventually form amyloid plaques that accumulate in Alzheimer's disease patients' brains. In this chapter, we highlight basic mechanism, structure, expression patterns and cleavage of amyloid plaques, and its diagnosis and potential treatment for Alzheimer's disease.

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KW - Amyloid beta

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KW - Diagnosis

KW - Expression patterns

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DO - 10.1016/bs.pmbts.2022.09.006

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AN - SCOPUS:85140799975

SN - 9780323955591

T3 - Progress in Molecular Biology and Translational Science

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BT - Receptor Endocytosis And Signalling In Health And Disease - Part B

A2 - Mani, Indra

A2 - Singh, Vijai

PB - Elsevier B.V.

ER -

Amyloid precursor protein in Alzheimer's disease

Abstract

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Keywords

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