@inbook{552354655cc1412ab0049b9596152d11,
title = "Amyloid precursor protein in Alzheimer's disease",
abstract = "Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity. It is encoded by the APP gene that is regulated by substrate presentation. APP is a precursor protein activated by proteolytic cleavage and thereby generating amyloid beta (Aβ) peptides which eventually form amyloid plaques that accumulate in Alzheimer's disease patients' brains. In this chapter, we highlight basic mechanism, structure, expression patterns and cleavage of amyloid plaques, and its diagnosis and potential treatment for Alzheimer's disease.",
keywords = "Alzheimer's disease, Amyloid beta, Amyloid precursor protein, Diagnosis, Expression patterns",
author = "Rupesh Maurya and Gargi Bhattacharjee and Khushal Khambhati and Nisarg Gohil and Priyanka Singh and Indra Mani and Chu, {Dinh Toi} and Suresh Ramakrishna and Show, {Pau Loke} and Vijai Singh",
note = "Funding Information: N.G. and G.B. acknowledge the Indian Council of Medical Research of the Government of India for financial assistance as Senior Research Fellowship File No. 5/3/8/63/ITR-F/2020 and File No. 5/3/8/41/ITR-F/2022-ITR, respectively. P.S. gratefully acknowledge the Gujarat State Biotechnology Mission for financial assistance as Junior Research Fellowship (Project ID: 5LY45F). The financial assistance from National Research Foundation of Korea (2021M3A9H3015389) and the Korean Fund for Regenerative Medicine (KFRM) grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) (22A0304L1-01) to S.R. is acknowledged. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
month = jan,
doi = "10.1016/bs.pmbts.2022.09.006",
language = "British English",
isbn = "9780323955591",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "261--270",
editor = "Indra Mani and Vijai Singh",
booktitle = "Receptor Endocytosis And Signalling In Health And Disease - Part B",
address = "Netherlands",
}