Alkylation of oxazolones and related heterocycles through an SN1 reaction

Andrea Nekane R. Alba, Teresa Calbet, Mercé Font-Bardía, Albert Moyano, Ramon Rios

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14 Scopus citations


The alkylation of oxazolones through an SN1 reaction by using stabilized carbocations is reported. The reaction (catalyzed by Brønsted acids, such as TFA or thioureas) affords the final compounds in excellent yields. Reaction with other heterocycles has also been studied, rendering pyrazolone or oxindole derivatives in good yields.

Original languageBritish English
Pages (from-to)2053-2056
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number11
StatePublished - Apr 2011


  • Alcohols
  • Brønsted acids
  • Green chemistry
  • Lewis acids
  • Nucleophilic substitution


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