AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

Michel Lagarde, Mayssa Hachem, Madeleine Picq, Michel Guichardant, Nathalie Bernoud-Hubac

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC® a promising phospholipid carrier of DHA to the brain.

Original languageBritish English
Article numberD102
JournalOCL - Oilseeds and fats, Crops and Lipids
Volume23
Issue number1
DOIs
StatePublished - 1 Jan 2016

Keywords

  • AceDoPC®
  • Acetyl-LysoPC-DHA
  • Blood-brain barrier
  • Carrier

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