AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

Michel Lagarde; Mayssa Hachem; Madeleine Picq; Michel Guichardant; Nathalie Bernoud-Hubac

doi:10.1051/ocl/2015061

AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

Michel Lagarde, Mayssa Hachem, Madeleine Picq, Michel Guichardant, Nathalie Bernoud-Hubac

Chemistry

Université de Lyon

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

AceDoPC^® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC^® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC^® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC^® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC^® a promising phospholipid carrier of DHA to the brain.

Original language	British English
Article number	D102
Journal	OCL - Oilseeds and fats, Crops and Lipids
Volume	23
Issue number	1
DOIs	https://doi.org/10.1051/ocl/2015061
State	Published - 1 Jan 2016

Keywords

AceDoPC®
Acetyl-LysoPC-DHA
Blood-brain barrier
Carrier

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1051/ocl/2015061

Cite this

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title = "AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid",

abstract = "AceDoPC{\textregistered} is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC{\textregistered} allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC{\textregistered} is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC{\textregistered} prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC{\textregistered} a promising phospholipid carrier of DHA to the brain.",

keywords = "AceDoPC{\textregistered}, Acetyl-LysoPC-DHA, Blood-brain barrier, Carrier",

author = "Michel Lagarde and Mayssa Hachem and Madeleine Picq and Michel Guichardant and Nathalie Bernoud-Hubac",

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T1 - AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

AU - Lagarde, Michel

AU - Hachem, Mayssa

AU - Picq, Madeleine

AU - Guichardant, Michel

AU - Bernoud-Hubac, Nathalie

N1 - Publisher Copyright: © M. Lagarde et al., published by EDP Sciences, 2015.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC® a promising phospholipid carrier of DHA to the brain.

AB - AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC® a promising phospholipid carrier of DHA to the brain.

KW - AceDoPC®

KW - Acetyl-LysoPC-DHA

KW - Blood-brain barrier

KW - Carrier

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U2 - 10.1051/ocl/2015061

DO - 10.1051/ocl/2015061

M3 - Article

AN - SCOPUS:85000631015

SN - 2272-6977

VL - 23

JO - OCL - Oilseeds and fats, Crops and Lipids

JF - OCL - Oilseeds and fats, Crops and Lipids

IS - 1

M1 - D102

ER -

AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

Abstract

Keywords

UN SDGs

Access to Document

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