A three-dimensional continuum model of active contraction in single cardiomyocytes

Alessio Gizzi, Ricardo Ruiz-Baier, Simone Rossi, Aymen Laadhari, Christian Cherubini, Simonetta Filippi

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We investigate the interaction of intracellular calcium spatio-temporal variations with the self-sustained contractions in cardiac myocytes. A 3D continuum mathematical model is presented based on a hyperelastic description of the passive mechanical properties of the cell, combined with an active-strain framework to describe the active shortening of myocytes and its coupling with cytosolic and sarcoplasmic calcium dynamics. Some numerical tests of combined boundary conditions and ionic activations illustrate the ability of our model in reproducing key experimentally established features. Potential applications of the study for predicting pathological subcellular mechanisms affecting e.g. cardiac repolarization are discussed.

Original languageBritish English
Pages (from-to)157-176
Number of pages20
JournalModeling, Simulation and Applications
StatePublished - 2015


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