A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis

  • Ramon Rios
  • , Ismail Ibrahem
  • , Jan Vesely
  • , Gui Ling Zhao
  • , Armando Córdova

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and α,β-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91-99% ee.

Original languageBritish English
Pages (from-to)5701-5705
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number32
DOIs
StatePublished - 6 Aug 2007

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