A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis

Ramon Rios; Ismail Ibrahem; Jan Vesely; Gui Ling Zhao; Armando Córdova

doi:10.1016/j.tetlet.2007.05.176

A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis

Ramon Rios
, Ismail Ibrahem
, Jan Vesely
, Gui Ling Zhao
, Armando Córdova

Chemistry

Arrhenius Laboratory

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and α,β-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91-99% ee.

Original language	British English
Pages (from-to)	5701-5705
Number of pages	5
Journal	Tetrahedron Letters
Volume	48
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2007.05.176
State	Published - 6 Aug 2007

Access to Document

10.1016/j.tetlet.2007.05.176

OpenUrl availability

Full text

Cite this

@article{721db841593f49ac9c491d6b24dcf249,

title = "A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis",

abstract = "The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and α,β-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91-99\% ee.",

author = "Ramon Rios and Ismail Ibrahem and Jan Vesely and Zhao, \{Gui Ling\} and Armando C{\'o}rdova",

note = "Funding Information: We gratefully acknowledge the Swedish National Research Council, Wenner-Gren and Carl-Trygger Foundations for financial support. ",

year = "2007",

month = aug,

day = "6",

doi = "10.1016/j.tetlet.2007.05.176",

language = "British English",

volume = "48",

pages = "5701--5705",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "32",

}

TY - JOUR

T1 - A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis

AU - Rios, Ramon

AU - Ibrahem, Ismail

AU - Vesely, Jan

AU - Zhao, Gui Ling

AU - Córdova, Armando

N1 - Funding Information: We gratefully acknowledge the Swedish National Research Council, Wenner-Gren and Carl-Trygger Foundations for financial support.

PY - 2007/8/6

Y1 - 2007/8/6

N2 - The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and α,β-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91-99% ee.

AB - The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and α,β-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91-99% ee.

UR - https://www.scopus.com/pages/publications/34447268984

U2 - 10.1016/j.tetlet.2007.05.176

DO - 10.1016/j.tetlet.2007.05.176

M3 - Article

AN - SCOPUS:34447268984

SN - 0040-4039

VL - 48

SP - 5701

EP - 5705

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis

Abstract

Access to Document

OpenUrl availability

Other files and links

Fingerprint

Cite this