A quantitative contour analysis of axisymmetric vesicles spontaneously adhering onto a substrate

Tan Xiao; Ning Fang; Vincent Chan; Kin Liao

doi:10.1016/j.colsurfb.2003.11.001

A quantitative contour analysis of axisymmetric vesicles spontaneously adhering onto a substrate

Tan Xiao
, Ning Fang
, Vincent Chan
, Kin Liao

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The determination of membrane-substrate profile for adherent vesicle using confocal reflectance interference contrast microscopy (C-RICM) has pushed for the need of advanced mechanics model for interpreting adhesion mechanisms. In this work, a model for vesicles or cells adhesion is established, the governing equation is derived from the variation of the potential energy at the cohesive zone. A closed-form solution is found for vesicle spontaneously adheres to a substrate when its shear modulus, μ vanishes. Based on the model and C-RICM experiments the magnitude of the adhesion force is calculated for a lipid vesicle adheres to a glass substrate.

Original language	British English
Pages (from-to)	25-31
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2003.11.001
State	Published - 1 Mar 2004

Keywords

Energy method
Mechanical model
Reflectance interference contrast microscopy
Vesicle adhesion

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10.1016/j.colsurfb.2003.11.001

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title = "A quantitative contour analysis of axisymmetric vesicles spontaneously adhering onto a substrate",

abstract = "The determination of membrane-substrate profile for adherent vesicle using confocal reflectance interference contrast microscopy (C-RICM) has pushed for the need of advanced mechanics model for interpreting adhesion mechanisms. In this work, a model for vesicles or cells adhesion is established, the governing equation is derived from the variation of the potential energy at the cohesive zone. A closed-form solution is found for vesicle spontaneously adheres to a substrate when its shear modulus, μ vanishes. Based on the model and C-RICM experiments the magnitude of the adhesion force is calculated for a lipid vesicle adheres to a glass substrate.",

keywords = "Energy method, Mechanical model, Reflectance interference contrast microscopy, Vesicle adhesion",

author = "Tan Xiao and Ning Fang and Vincent Chan and Kin Liao",

note = "Funding Information: The authors gratefully acknowledge the financial support of this work by Singapore-University of Washington Alliance (SUWA) on Bioengineering.",

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AU - Xiao, Tan

AU - Fang, Ning

AU - Chan, Vincent

AU - Liao, Kin

N1 - Funding Information: The authors gratefully acknowledge the financial support of this work by Singapore-University of Washington Alliance (SUWA) on Bioengineering.

PY - 2004/3/1

Y1 - 2004/3/1

N2 - The determination of membrane-substrate profile for adherent vesicle using confocal reflectance interference contrast microscopy (C-RICM) has pushed for the need of advanced mechanics model for interpreting adhesion mechanisms. In this work, a model for vesicles or cells adhesion is established, the governing equation is derived from the variation of the potential energy at the cohesive zone. A closed-form solution is found for vesicle spontaneously adheres to a substrate when its shear modulus, μ vanishes. Based on the model and C-RICM experiments the magnitude of the adhesion force is calculated for a lipid vesicle adheres to a glass substrate.

AB - The determination of membrane-substrate profile for adherent vesicle using confocal reflectance interference contrast microscopy (C-RICM) has pushed for the need of advanced mechanics model for interpreting adhesion mechanisms. In this work, a model for vesicles or cells adhesion is established, the governing equation is derived from the variation of the potential energy at the cohesive zone. A closed-form solution is found for vesicle spontaneously adheres to a substrate when its shear modulus, μ vanishes. Based on the model and C-RICM experiments the magnitude of the adhesion force is calculated for a lipid vesicle adheres to a glass substrate.

KW - Energy method

KW - Mechanical model

KW - Reflectance interference contrast microscopy

KW - Vesicle adhesion

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JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

A quantitative contour analysis of axisymmetric vesicles spontaneously adhering onto a substrate

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Keywords

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