A quantitative contour analysis of axisymmetric vesicles spontaneously adhering onto a substrate

Tan Xiao, Ning Fang, Vincent Chan, Kin Liao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The determination of membrane-substrate profile for adherent vesicle using confocal reflectance interference contrast microscopy (C-RICM) has pushed for the need of advanced mechanics model for interpreting adhesion mechanisms. In this work, a model for vesicles or cells adhesion is established, the governing equation is derived from the variation of the potential energy at the cohesive zone. A closed-form solution is found for vesicle spontaneously adheres to a substrate when its shear modulus, μ vanishes. Based on the model and C-RICM experiments the magnitude of the adhesion force is calculated for a lipid vesicle adheres to a glass substrate.

Original languageBritish English
Pages (from-to)25-31
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume34
Issue number1
DOIs
StatePublished - 1 Mar 2004

Keywords

  • Energy method
  • Mechanical model
  • Reflectance interference contrast microscopy
  • Vesicle adhesion

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