A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails

Dimitris G. Patsatzis, Dimitris A. Goussis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The Michaelis-Menten reaction scheme is among the most influential models in the field of biochemistry, since it led to a very popular expression for the rate of an enzyme-catalysed reaction. After the realisation that this expression is valid in a limited region of the parameter space, two additional expressions were later introduced. The range of validity of these three expressions has been studied thoroughly, since the significance of a reliable rate is not based only on the accuracy of its predictive abilities but also on the physical insight that is acquired in the process of its construction. Here a new expression for the rate is introduced that is valid in practically the full parameter space and reduces to the expressions in the literature, when considering appropriate limits. The new expression is produced by employing algorithmic tools for asymptotic analysis, so that its construction is not hindered by the dimensional form and the complexity of the full model or by a wide parameter range of interest. These tools can be employed for the derivation of enzyme rate expressions of much more complex kinetics mechanisms.

Original languageBritish English
Article number108220
JournalMathematical Biosciences
Volume315
DOIs
StatePublished - Sep 2019

Keywords

  • CSP
  • Michaelis-Menten
  • Reduced model
  • rQSSA
  • sQSSA

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