A Microfluidic Ion Pump for In Vivo Drug Delivery

Ilke Uguz, Christopher M. Proctor, Vincenzo F. Curto, Anna Maria Pappa, Mary J. Donahue, Magali Ferro, Róisín M. Owens, Dion Khodagholy, Sahika Inal, George G. Malliaras

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.

Original languageBritish English
Article number1701217
JournalAdvanced Materials
Volume29
Issue number27
DOIs
StatePublished - 19 Jul 2017

Keywords

  • organic bioelectronics
  • organic electronic ion pumps
  • PEDOT:PSS

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