3D and 4D Bioprinting Technologies: A Game Changer for the Biomedical Sector?

Reza Noroozi, Zia Ullah Arif, Hadi Taghvaei, Muhammad Yasir Khalid, Hossein Sahbafar, Amin Hadi, Ali Sadeghianmaryan, Xiongbiao Chen

    Research output: Contribution to journalReview articlepeer-review

    57 Scopus citations

    Abstract

    Bioprinting is an innovative and emerging technology of additive manufacturing (AM) and has revolutionized the biomedical sector by printing three-dimensional (3D) cell-laden constructs in a precise and controlled manner for numerous clinical applications. This approach uses biomaterials and varying types of cells to print constructs for tissue regeneration, e.g., cardiac, bone, corneal, cartilage, neural, and skin. Furthermore, bioprinting technology helps to develop drug delivery and wound healing systems, bio-actuators, bio-robotics, and bio-sensors. More recently, the development of four-dimensional (4D) bioprinting technology and stimuli-responsive materials has transformed the biomedical sector with numerous innovations and revolutions. This issue also leads to the exponential growth of the bioprinting market, with a value over billions of dollars. The present study reviews the concepts and developments of 3D and 4D bioprinting technologies, surveys the applications of these technologies in the biomedical sector, and discusses their potential research topics for future works. It is also urged that collaborative and valiant efforts from clinicians, engineers, scientists, and regulatory bodies are needed for translating this technology into the biomedical, pharmaceutical, and healthcare systems.

    Original languageBritish English
    Pages (from-to)1683-1712
    Number of pages30
    JournalAnnals of Biomedical Engineering
    Volume51
    Issue number8
    DOIs
    StatePublished - Aug 2023

    Keywords

    • 3D bioprinting
    • 4D bioprinting
    • Additive manufacturing
    • Biomedical applications
    • Tissue engineering

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